New coupling strategy for radionuclide labeling of synthetic polymers.
Identifieur interne : 001851 ( Main/Exploration ); précédent : 001850; suivant : 001852New coupling strategy for radionuclide labeling of synthetic polymers.
Auteurs : RBID : pubmed:20004106English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Azo Compounds, Polymers, Radioisotopes.
- methods : Isotope Labeling.
Abstract
We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
DOI: 10.1016/j.apradiso.2009.11.039
PubMed: 20004106
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">New coupling strategy for radionuclide labeling of synthetic polymers.</title><author><name sortKey="Hruby, Martin" uniqKey="Hruby M">Martin Hruby</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6</wicri:regionArea></affiliation></author><author><name sortKey="Kucka, Jan" uniqKey="Kucka J">Jan Kucka</name></author><author><name sortKey="Novakova, Michaela" uniqKey="Novakova M">Michaela Novakova</name></author><author><name sortKey="Mackova, Hana" uniqKey="Mackova H">Hana Mackova</name></author><author><name sortKey="Vetrik, Miroslav" uniqKey="Vetrik M">Miroslav Vetrik</name></author></titleStmt><publicationStmt><date when="2010">2010</date><idno type="doi">10.1016/j.apradiso.2009.11.039</idno><idno type="RBID">pubmed:20004106</idno><idno type="pmid">20004106</idno><idno type="wicri:Area/Main/Corpus">001B76</idno><idno type="wicri:Area/Main/Curation">001B76</idno><idno type="wicri:Area/Main/Exploration">001851</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Azo Compounds (chemistry)</term><term>Isotope Labeling (methods)</term><term>Polymers (chemistry)</term><term>Radioisotopes (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Azo Compounds</term><term>Polymers</term><term>Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Isotope Labeling</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20004106</PMID><DateCreated><Year>2010</Year><Month>02</Month><Day>03</Day></DateCreated><DateCompleted><Year>2010</Year><Month>03</Month><Day>15</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9800</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>2</Issue><PubDate><Year>2010</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine</Title><ISOAbbreviation>Appl Radiat Isot</ISOAbbreviation></Journal><ArticleTitle>New coupling strategy for radionuclide labeling of synthetic polymers.</ArticleTitle><Pagination><MedlinePgn>334-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.apradiso.2009.11.039</ELocationID><Abstract><AbstractText>We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.</AbstractText><CopyrightInformation>Copyright (c) 2009 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hruby</LastName><ForeName>Martin</ForeName><Initials>M</Initials><Affiliation>Institute of Macromolecular Chemistry AS CR, v.v.i., Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic. mhruby@centrum.cz</Affiliation></Author><Author ValidYN="Y"><LastName>Kucka</LastName><ForeName>Jan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Novakova</LastName><ForeName>Michaela</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Mackova</LastName><ForeName>Hana</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Vetrik</LastName><ForeName>Miroslav</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2009</Year><Month>11</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Appl Radiat Isot</MedlineTA><NlmUniqueID>9306253</NlmUniqueID><ISSNLinking>0969-8043</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Azo Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Polymers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Azo Compounds</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Isotope Labeling</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Polymers</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2009</Year><Month>8</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2009</Year><Month>11</Month><Day>4</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2009</Year><Month>11</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2009</Year><Month>11</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0969-8043(09)00728-3</ArticleId><ArticleId IdType="doi">10.1016/j.apradiso.2009.11.039</ArticleId><ArticleId IdType="pubmed">20004106</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001851 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001851 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:20004106
|texte= New coupling strategy for radionuclide labeling of synthetic polymers.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20004106" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |